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HMG-X, a Xenopus gene encoding an HMG1 homolog, is abundantly expressed in the developing nervous system
M Kinoshita1, S Hatada, M Asashima
1Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
FEBS Letters
|September 26, 1994
Abstract:
We used a PCR-based subtraction cloning procedure with Concanavalin A-treated and untreated animal caps from stage 9 Xenopus embryos to search for genes the expression of which is induced during neurogenesis. One of these genes was found to encode a homolog of mammalian HMG 1 and 2, hence named HMG-X. HMG-X mRNA was maternally transmitted, up-regulated in neuroectoderm-derived tissues throughout early development, and eventually down-regulated in all adult tissues examined except ovary. Our data suggest that we have identified a gene for a member of the HMG1/2 family that could have an important role in neurogenesis.