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Essential fatty acids and malignant disease

P Purasiri¹, S D Heys, O Eremin

¹Department of Surgery, University of Aberdeen, UK.

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|October 1, 1994

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Essential fatty acids (EFAs) show anti-tumour potential in lab studies but may suppress human immune responses. More research is needed to clarify their role in cancer treatment.

Area of Science:

Oncology
Immunology
Nutritional Science

Background:

Essential fatty acids (EFAs) demonstrate potential anti-tumour activity in preclinical models.
EFAs possess immunomodulatory properties that can impact host defense mechanisms.

Purpose of the Study:

To evaluate the dual role of EFAs in cancer therapy.
To investigate the immunomodulatory effects of EFAs in humans concerning anti-tumour immunity.

Main Methods:

Review of existing cell culture and animal model studies on EFA anti-tumour effects.
Analysis of human studies examining EFA impact on immune functions like natural cytotoxicity and cytokine production.

Main Results:

Preclinical data suggest EFAs inhibit tumor growth.

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Human studies indicate EFAs can suppress key immune responses, including natural cytotoxicity and cytokine production, which are crucial for anti-tumour defense.

Conclusions:

The therapeutic application of EFAs in human cancer requires careful consideration due to their immunosuppressive effects.
Further rigorous investigation is necessary to precisely define the role of EFAs in managing malignant diseases in humans.