Related Experiment Video
Updated: Jul 20, 2026
Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
Published on: August 11, 2023
Differences in serum follicle-stimulating hormone uptake after intramuscular and subcutaneous human menopausal
K E Dobbs1, D A Dumesic, J A Dumesic
1Department of Obstetrics and Gynecology, University of Wisconsin, Madison.
Objective:
To determine the difference in FSH bioavailability from IM and SC injection sites.
Design:
Menotropin was injected into either an IM or SC site in women undergoing ovarian suppression with leuprolide acetate. Serial serum samples were obtained over 96 hours.
Setting:
Academic tertiary care institution.
Patients:
Seven volunteer cycling women.
Main Outcome Measures:
Follicle-stimulating hormone, LH, and E2 were determined in serial serum samples.
Results:
Peak serum FSH levels were higher and occurred earlier after IM injection than after SC injection. Computed absorption rate constants for FSH after IM and SC injection differed significantly.
Conclusions:
The pharmacokinetics of FSH differ after a single IM or SC injection.
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