Multiple myeloma associated with autoimmune hemolytic anemia
G Vaiopoulos1, D Kyriakou, H Papadaki
1First Department of Internal Medicine of the University of Athens School of Medicine, Laiko General Hospital, Greece.
Abstract:
A rare case of multiple myeloma associated with severe Coombs-positive hemolytic anemia is described. A 60-year-old woman was hospitalized for acute hemolysis due to an IgG warm autoantibody with pan-agglutinin specificity. Serum and urine electrophoresis revealed the presence of a monoclonal IgGk protein and a BJk protein, respectively. Bone marrow aspirates showed diffuse infiltration with plasma cells, and skeletal survey revealed lytic lesions in the skull and diffuse osteoporosis. Treatment with prednisone, and subsequently with melphalan, cyclophosphamide and vincristine resulted in hematological improvement within two weeks. A reduction of paraprotein below 50% of the initial levels was found after six months of therapy.
Related Concept Videos
Hybridoma Technology
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune system...
Hypersensitivity Reactions: Cytolytic Reactions
Multiple Sclerosis l: Introduction
Myasthenia Gravis ll: Pathophysiology


