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[Transient unresponsiveness of the elderly]

H Semu1, S Levenkron

  • 1Geriatric Dept., Chaim Sheba Medical Center, Tel Hashomer.

Harefuah
|August 1, 1994
PubMed
Summary

Recurrent transient unresponsiveness, unexplained by common causes, may stem from disrupted brain connectivity. A history of transient ischemic attacks (TIAs) is a common factor in these patients.

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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Transient unresponsiveness presents a diagnostic challenge.
  • Differential diagnoses include metabolic disorders, arrhythmias, and seizures, which were ruled out in this case.

Observation:

  • An 81-year-old woman presented with recurrent episodes of transient unresponsiveness.
  • Literature review identified 5 similar cases with no clear etiology after extensive investigation.

Findings:

  • Suggested causes for these episodes include diffuse ischemia or sleep disorders.
  • The proposed mechanism involves a functional discontinuity between the reticular formation and the cerebral cortex.
  • A shared characteristic among these patients is a history of recurrent transient ischemic attacks (TIAs).

Implications:

  • This suggests TIAs may predispose individuals to unexplained transient unresponsiveness.
  • Further research is needed to elucidate the precise pathophysiological link.
  • Understanding this connection could lead to improved diagnostic and therapeutic strategies for such neurological events.

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