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Gastrointestinal lymphoma

P G Isaacson1

  • 1Department of Histopathology, University College London Medical School, UK.

Human Pathology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Primary gastrointestinal lymphomas are diverse B- and T-cell malignancies. Mucosa-associated lymphoid tissue (MALT) lymphomas, often in the stomach linked to Helicobacter pylori, are common and can transform.

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Area of Science:

  • Gastroenterology
  • Hematology
  • Oncology

Background:

  • Primary gastrointestinal lymphomas are distinct clinicopathological entities often unclassified by lymph node-based systems.
  • Most are B-cell or T-cell types, with primary gastrointestinal Hodgkin's disease being rare.
  • Low-grade B-cell lymphomas are frequently of the mucosa-associated lymphoid tissue (MALT) type.

Purpose of the Study:

  • To review the clinicopathological features of primary gastrointestinal lymphomas.
  • To discuss the pathogenesis and classification of these diverse entities.
  • To highlight the association of gastric MALT lymphomas with Helicobacter pylori infection.

Main Methods:

  • Review of existing literature and clinicopathological data.
  • Analysis of lymphoma classification systems.

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  • Discussion of pathogenetic mechanisms and clinical behavior.

    • Main Results:

    • Gastric MALT lymphomas arise from acquired lymphoid tissue, often linked to Helicobacter pylori infection, and can be influenced by its eradication.
    • Low-grade MALT lymphomas may transform into high-grade tumors, while high-grade tumors can also arise de novo.
    • Other B-cell lymphomas include mantle cell lymphoma and Burkitt's lymphoma.
    • Enteropathy (celiac disease)-associated T-cell lymphoma (EATL) is an aggressive T-cell lymphoma arising in celiac disease patients.

    Conclusions:

    • Primary gastrointestinal lymphomas encompass a heterogeneous group of B- and T-cell neoplasms.
    • Gastric MALT lymphoma pathogenesis is linked to Helicobacter pylori, offering potential therapeutic targets.
    • Enteropathy-associated T-cell lymphoma represents a distinct aggressive T-cell malignancy in celiac disease.