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[Systemic B-cell response in the mouse after mucosal immunization with measles virus]
1Laboratoire National de Santé, Luxemburg.
Immunitat Und Infektion
|June 1, 1994
Summary
Intranasal measles virus (MV) immunization in mice induced hemagglutination-inhibiting antibodies but lacked neutralizing activity. Intragastric immunization showed no detectable virus-specific antibody response, suggesting limitations for mucosal delivery routes.
Area of Science:
- Immunology
- Virology
- Vaccinology
Context:
- The respiratory tract is the primary entry point for the measles virus (MV) and a key site for complications.
- Current measles vaccination is administered subcutaneously.
- Mucosal immunization presents a potential alternative route for measles vaccination.
Purpose:
- To investigate the immunogenicity of intranasal and intragastric measles virus immunization in a mouse model.
- To evaluate the resulting serum IgA and IgG antibody responses under non-replicating conditions.
Summary:
- Mice received intranasal or intragastric measles virus immunization without replication.
- Intranasal immunization elicited serum hemagglutination-inhibiting antibodies, but these generally lacked virus-neutralizing capacity.
- Intragastric immunization did not induce any detectable measles virus-specific antibodies.
Impact:
- This study highlights the challenges of achieving effective systemic immunity via non-replicating mucosal measles virus immunization.
- Findings suggest that intranasal delivery may induce some humoral response, while intragastric delivery is ineffective.
- Further research is needed to optimize mucosal vaccine strategies for measles to potentially enhance respiratory tract immunity.