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Correlation of phospholipase A & enterotoxin production by Salmonella typhimurium with reference to virulence

M Shetty1, K L Bairy, S Krishnananda

  • 1Department of Microbiology, Kasturba Medical College, Manipal.

The Indian Journal of Medical Research
|April 1, 1994
PubMed

Insights

Phospholipase A (PLA) activity was detected in some Salmonella strains. PLA activity correlated with enterotoxin production, antibiotic resistance, and cell surface hydrophobicity in Salmonella typhimurium.

Area of Science:

  • Microbiology
  • Bacteriology
  • Molecular Biology

Background:

  • Salmonella species are significant foodborne pathogens.
  • Virulence factors are crucial for Salmonella pathogenesis.
  • Phospholipase A (PLA) is a potential virulence factor in bacteria.

Purpose of the Study:

  • To investigate the phospholipase A (PLA) activity in various Salmonella serotypes.
  • To determine the correlation between PLA activity and other virulence factors in Salmonella typhimurium.

Main Methods:

  • Phenotypic screening of 95 Salmonella strains for PLA activity.
  • Assessing enterotoxin production, hemolytic activity, surface hydrophobicity, and antibiotic sensitivity in PLA-positive S. typhimurium strains.

Main Results:

  • Phospholipase A (PLA) activity was detected in 17.14% of Salmonella typhimurium strains.
  • A significant correlation was observed between PLA activity and enterotoxin production.
  • PLA activity also showed a strong correlation with antibiotic sensitivity and cell surface hydrophobicity.

Conclusions:

  • PLA is a potential virulence marker in Salmonella typhimurium.
  • PLA activity is linked to key pathogenic traits, including enterotoxin production and host cell interaction.
  • These findings contribute to understanding Salmonella virulence mechanisms.

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