Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Staphylococcus saprophyticus hemagglutinin binds fibronectin

S Gatermann1, H G Meyer

  • 1Institut für Medizinische Mikrobiologie, Medizinische Universität zu Lübeck, Germany.

Infection and Immunity
|October 1, 1994
PubMed
Summary

Staphylococcus saprophyticus hemagglutinin binds to fibronectin, a human protein. This suggests the hemagglutinin may function as a fibronectin receptor, aiding bacterial attachment during infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endoscope-associated outbreak of OXA-181-carbapenemase-producing Klebsiella pneumoniae and its implications for hygiene management.

The Journal of hospital infection·2025
Same author

[Management of Adult Community-Acquired Pneumonia and Prevention - Update 2021 - Guideline of the German Respiratory Society (DGP), the Paul-Ehrlich-Society for Chemotherapy (PEG), the German Society for Infectious Diseases (DGI), the German Society of Medical Intensive Care and Emergency Medicine (DGIIN), the German Viological Society (DGV), the Competence Network CAPNETZ, the German College of General Practitioneers and Family Physicians (DEGAM), the German Society for Geriatric Medicine (DGG), the German Palliative Society (DGP), the Austrian Society of Pneumology Society (ÖGP), the Austrian Society for Infectious and Tropical Diseases (ÖGIT), the Swiss Respiratory Society (SGP) and the Swiss Society for Infectious Diseases Society (SSI)].

Pneumologie (Stuttgart, Germany)·2021
Same author

Pneumologie (Stuttgart, Germany)·2020
Same author

[Epidemiology, Diagnosis and Treatment of Adult Patients with Nosocomial Pneumonia - Update 2017 - S3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy, the German Radiological Society and the Society for Virology].

Pneumologie (Stuttgart, Germany)·2018
Same author

[Criteria for treating MRSA in sputum].

Der Internist·2017
Same author

[Management of Adult Community-acquired Pneumonia and Prevention - Update 2016].

Pneumologie (Stuttgart, Germany)·2016

Area of Science:

  • Microbiology
  • Pathogenesis
  • Molecular Biology

Background:

  • Bacterial attachment to host tissues is crucial for infection development.
  • Staphylococcus saprophyticus adheres to epithelial cells and causes hemagglutination.
  • The specific human target for S. saprophyticus hemagglutinin remains unidentified.

Purpose of the Study:

  • To identify the human target of Staphylococcus saprophyticus hemagglutinin.
  • To investigate the role of hemagglutinin in bacterial adhesion to host tissues.

Main Methods:

  • Testing the binding of S. saprophyticus strains to immobilized fibronectin.
  • Using antibodies to inhibit bacterial binding and identify involved surface proteins.
  • Assessing the binding of purified hemagglutinin to fibronectin.

Main Results:

  • Hemagglutinating S. saprophyticus strains bind to fibronectin; non-hemagglutinating strains do not.
  • Antibody against hemagglutinin inhibited binding, while antibody against Ssp did not.
  • Purified hemagglutinin specifically bound fibronectin in a saturable manner.

Conclusions:

  • The hemagglutinin of S. saprophyticus likely functions as a fibronectin receptor in humans.
  • This interaction may mediate bacterial adherence to host tissues.
  • The fibronectin binding site on hemagglutinin differs from that of other pathogens.

Related Experiment Videos