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Quinolone resistance in Pseudomonas aeruginosa and Staphylococcus aureus. Development during therapy and clinical

A Dalhoff1

  • 1Institut für Chemotherapie, Wuppertal, Germany.

Infection
|January 1, 1994
PubMed

Insights

Quinolone resistance emerges sporadically, often in specific patient groups and settings. This resistance is primarily due to the clonal spread of a single resistant strain, not independent selections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Fluoroquinolone antibiotics are widely used for treating bacterial infections.
  • The emergence of antimicrobial resistance is a significant global health concern.

Purpose of the Study:

  • To review experimental and clinical data on the emergence of quinolone-resistant bacterial isolates.
  • To understand the mechanisms and epidemiological patterns of quinolone resistance.

Main Methods:

  • Review of published literature on quinolone resistance.
  • Analysis of experimental and clinical data regarding resistant isolates.
  • Examination of epidemiological studies on resistance patterns.

Main Results:

  • Sporadic emergence of quinolone resistance during clinical fluoroquinolone use.
  • Resistance often occurs in specific clinical settings with high bacterial loads or suboptimal drug concentrations.
  • Hospitalized and nursing-home patients with risk factors show higher incidence.
  • Epidemiological studies indicate selection and horizontal transmission of a predominant resistant clone.

Conclusions:

  • Quinolone resistance emergence is largely attributed to the clonal spread of a single resistant strain.
  • The actual rate of quinolone resistance may be lower than currently reported due to this clonal selection mechanism.

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