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The spine in sickle cell disease
M Sadat-Ali1, A Ammar, J R Corea
1Department of Orthopaedic Surgery, College of Medicine and Medical Sciences, King Faisal University, Dammam, Saudi Arabia.
International Orthopaedics
|June 1, 1994
Summary
Sickle cell disease frequently impacts the spine, causing bone changes like vertebral collapse and infections. Early, aggressive treatment is crucial to prevent severe, disabling complications in patients.
Area of Science:
- Orthopedics
- Hematology
- Neurosurgery
Background:
- Sickle cell disease (SCD) causes bone complications via marrow hyperplasia, ischemia, and infarction.
- Spinal complications are a significant manifestation of SCD.
Purpose of the Study:
- To analyze the spectrum and management of spinal complications in patients with sickle cell disease.
Main Methods:
- Retrospective review of 34 patients treated for spinal complications of SCD between 1982-1991.
- Analysis of orthopedic and neurosurgical interventions.
Main Results:
- Vertebral body changes due to marrow hyperplasia occurred in 44% of patients.
- Avascular necrosis causing vertebral collapse was observed in 27% of patients.
- Infective spondylitis was seen in 24% of patients, often requiring decompression and bone grafting.
Conclusions:
- The spine is commonly affected in sickle cell disease.
- Aggressive treatment and close follow-up are essential to mitigate disabling spinal complications.
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