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[Continuous intratympanic gentamycin infusion in Menière disease]
P Küppers1, H Ahrens, R Blessing
1Klinik für Hals-, Nasen- und Ohrenheilkunde, Medizinischen Universität zu Lübeck.
HNO
|July 1, 1994
Summary
Continuous gentamicin infusion via endaural catheter offers an effective treatment for Ménière
Area of Science:
- Otolaryngology
- Nephrology
- Pharmacology
Context:
- Ménière's disease is a chronic inner ear disorder.
- Current treatments for Ménière's disease have limitations.
- Continuous gentamicin infusion offers a novel therapeutic approach.
Purpose:
- To evaluate the efficacy and safety of continuous gentamicin infusion for Ménière's disease.
- To compare continuous versus discontinuous gentamicin application.
- To assess the impact on vertigo, hearing, and overall quality of life.
Summary:
- 42 patients with Ménière's disease received continuous gentamicin infusion.
- Treatment involved a portable pump delivering 3 ml of 0.3% gentamicin daily.
- Significant reduction in vertigo frequency and intensity was observed, with 14 patients becoming vertigo-free.
Impact:
- Continuous gentamicin infusion resulted in stable or improved hearing thresholds in most patients.
- This method demonstrated a lower average gentamicin dose and fewer adverse effects compared to discontinuous therapy.
- The treatment offers a promising, well-tolerated option for managing Ménière's disease symptoms.