Related Experiment Videos
Synthesis of 5-epi-trehazolin (trehalostatin)
Y Kobayashi1, H Miyazaki, M Shiozaki
1Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|August 1, 1994
Abstract:
Synthesis of 5-epi-trehazolin (trehalostatin) (2) was accomplished via the crucial intermediate, epoxide (6 alpha), from D-glucose. The stereochemistry of epoxide (6 alpha) and its isomer (6 beta) which were obtained from Sharpless epoxidation, was determined by comparison between the NMR relaxation times of relevant protons.