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Diffusing capacity dependent on lung volume and age in normal subjects

H Stam1, V Hrachovina, T Stijnen

  • 1Department of Pulmonary Diseases, Erasmus University, Rotterdam, The Netherlands.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1994
PubMed
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This study establishes reference values for diffusing capacity of carbon monoxide (DLCO) and DLCO per liter alveolar volume (DLCO/VA) in healthy adults. Equations were derived to predict these lung function parameters at various lung volumes.

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Lung Function Testing

Background:

  • Accurate reference values for diffusing capacity of carbon monoxide (DLCO) and DLCO per liter alveolar volume (DLCO/VA) are crucial for diagnosing lung diseases.
  • Existing reference values may not adequately account for variations in lung volumes below total lung capacity (TLC).

Purpose of the Study:

  • To determine reference values for DLCO and DLCO/VA at total lung capacity (TLC) and below TLC in healthy adults.
  • To develop equations for calculating DLCO/VA reference values at various lung volumes.
  • To compare two methods for deriving these reference values.

Main Methods:

  • Studied 55 healthy non-smoking volunteers aged 20-85 years.
  • Measured DLCO and DLCO/VA at TLC and at lung volumes below TLC in a sitting position.

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  • Utilized a "random coefficients linear" model and a conversion method to derive reference equations.

    • Main Results:

    • Age was the primary determinant for DLCO/VA reference values at TLC.
    • DLCO decreased and DLCO/VA increased linearly with decreasing alveolar volume (VA).
    • The increase in DLCO/VA with decreasing VA was less pronounced in older subjects.

    Conclusions:

    • Established age-dependent reference values for DLCO and DLCO/VA at TLC.
    • Developed and validated methods for calculating DLCO/VA reference values across different lung volumes.
    • The findings provide essential data for interpreting lung diffusion capacity in clinical practice.