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Related Experiment Videos

A new function for lactate in the toad Bufo marinus

H O Pörtner1, L G Branco, G M Malvin

  • 1Lovelace Institutes, Albuquerque, New Mexico 87108.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1994
PubMed
Summary
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Lactate increases metabolic rate and triggers hypothermic behavior in toads during hypoxia. This suggests lactate may act as an emergency alarm signal, influencing physiological and behavioral responses.

Area of Science:

  • Physiology
  • Biochemistry
  • Animal Behavior

Background:

  • Progressive hypoxia in Bufo marinus causes increased oxygen consumption and lactate formation.
  • The relationship between lactate and metabolic rate during hypoxia requires further investigation.

Purpose of the Study:

  • To test the hypothesis that lactate directly causes the observed rise in metabolic rate during hypoxia.
  • To investigate the role of catecholamines and behavioral changes in response to lactate infusion.

Main Methods:

  • Arterial bolus infusions of sodium lactate solutions in hypoxic toads.
  • Administration of adrenergic antagonists (bretylium tosylate, phentolamine, propranolol, reserpine).
  • Observation of metabolic rate changes and behavioral responses (e.g., thermoregulation).

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Main Results:

  • Lactate infusion mimicked the hypoxia-induced increase in metabolic rate.
  • Adrenergic antagonists inhibited the lactate-induced metabolic response.
  • Lactate administration prompted behavioral hypothermia in toads.

Conclusions:

  • Lactate plays a direct role in elevating metabolic rate during hypoxia.
  • Catecholamines are involved in mediating the metabolic effects of lactate.
  • Lactate may function as an alarm signal, initiating beneficial adaptive responses like behavioral hypothermia.