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Long-term survivors of HIV infection
1Department of Medicine, University of California, San Francisco, School of Medicine.
Hospital Practice (Office Ed.)
|October 15, 1994
Abstract:
The persistent immune competence seen in a small percentage of HIV-infected individuals reflects the heterogeneity of both the virus and the host. Some HIV strains, for example, are more cytopathic than others. Host factors that promote longer survival lack "enhancing" antibodies, an appropriate balance of two crucial CD4+ cell subsets and their cytokines, and a strong CD8+ cell antiviral response.