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Characterization of rotavirus strains from newborns in New Delhi, India
B K Das1, J R Gentsch, H G Cicirello
1Department of Paediatrics and Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Insights
Rotavirus strains G9P11 and G9P6 were common in New Delhi hospital nurseries between 1986 and 1993. These findings highlight the prevalence of specific rotavirus genotypes in neonatal populations in India.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Rotavirus is a leading cause of severe diarrheal disease in infants globally.
- Understanding rotavirus strain prevalence is crucial for vaccine development and public health strategies.
- Previous studies indicated diverse rotavirus strains circulating in India.
Purpose of the Study:
- To characterize rotavirus strains isolated from newborns in New Delhi hospitals.
- To determine the common rotavirus genotypes and their prevalence during 1986-1993.
- To identify any novel or significant rotavirus strains in the studied population.
Main Methods:
- Collection of rotavirus strains from newborns across five New Delhi hospitals.
- Analysis of viral electropherotypes and VP6 antigens.
- Genotyping of G and P serotypes using molecular methods.
Main Results:
- 72% of isolates exhibited long electropherotypes, subgroup II VP6 antigens, and G9P11 genotype, matching prototype strain 116E.
- A novel G9P6 rotavirus strain was identified, accounting for 13% of isolates.
- Rotavirus G9P11 and G9P6 strains were found to be prevalent in neonatal settings.
Conclusions:
- G9P11 and G9P6 rotavirus strains were common in New Delhi nurseries during the study period.
- The findings underscore the epidemiological significance of these specific rotavirus genotypes in Indian neonates.
- Continued surveillance of rotavirus strains is essential for effective disease control.
Abstract:
Between 1986 and 1993, 72% of rotavirus strains isolated from newborns at five hospitals in New Delhi, India, had long electropherotypes, subgroup II VP6 antigens, and G and P genotypes (G9P11) identical to those of prototype strain 116E. A novel strain with a G9P6 genotype, representing 13% of the isolates, was identified. These results demonstrate that G9P11 and G9P6 rotavirus strains are common in nurseries in New Delhi.