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Mapping the bovine albino locus

M E Foreman1, M L Lamoreux, B Kwon

  • 1Battelle Northwest Laboratory, Biology Department, Richland, Washington.

The Journal of Heredity
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

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The bovine albino locus is syntenic with lactate dehydrogenase A (LDHA), unlike in other mammals where it is linked to beta-hemoglobin. This finding reveals significant chromosomal rearrangements in mammalian genome evolution.

Area of Science:

  • Comparative genomics
  • Mammalian genetics
  • Molecular cytogenetics

Background:

  • The albino, beta-hemoglobin (HBB), and lactate dehydrogenase A (LDHA) loci form a conserved syntenic group in many mammals.
  • Previous genetic mapping studies have established synteny relationships for these loci in various species.

Purpose of the Study:

  • To map the bovine albino locus using a human tyrosinase cDNA probe.
  • To investigate the synteny of the bovine albino locus in relation to HBB and LDHA.

Main Methods:

  • Utilized a human tyrosinase cDNA clone (Pme134) as a probe.
  • Employed a panel of bovine-hamster hybrid cells for gene mapping.
  • Analyzed synteny relationships with previously mapped loci including HBB and LDHA.

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Main Results:

  • The bovine albino locus is not syntenic with the beta-hemoglobin locus, contrary to findings in mice, rats, cats, and rabbits.
  • The tyrosinase probe hybridized to a fragment syntenic with the lactate dehydrogenase A (LDHA) locus in cattle.
  • Identified conserved synteny between HBB and catalase (CAT) in humans and cattle, but not in mice.

Conclusions:

  • The chromosomal organization of the albino, HBB, and LDHA loci has undergone significant rearrangements during mammalian evolution.
  • At least two chromosomal rearrangements are inferred to explain the divergent synteny relationships of HBB, CAT, LDHA, and the albino locus across species.