Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cutaneous blood flow abnormalities in hypertriglyceridemia

E Tur1, Y Politi, A Rubinstein

  • 1Department of Dermatology, Elias-Sourasky Medical Center, Tel Aviv University, Israel.

The Journal of Investigative Dermatology
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of the acceptability of effervescent oxycodone/paracetamol in the management of moderate-to-severe pain: the FirAlgos study.

European review for medical and pharmacological sciences·2026
Same author

Restoration of energy homeostasis by SIRT6 extends healthy lifespan.

Nature communications·2021
Same author

Ideal Cardiovascular Health in the southern cone of Latin America.

Public health·2018
Same author

Prevention of childhood obesity and food policies in Latin America: from research to practice.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2017
Same author

Single point mutation detection in living cancer cells by far-red emitting PNA-FIT probes.

Chemical communications (Cambridge, England)·2016
Same author

Lower tract respiratory infection in children younger than 5 years of age and adverse pregnancy outcomes related to household air pollution in Bariloche (Argentina) and Temuco (Chile).

Indoor air·2015
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026
Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026
Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026
Same journal

Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

The Journal of investigative dermatology·2026
See all related articles

Hypertriglyceridemia impairs forearm blood flow, indicated by reduced postischemic reactive hyperemia. Treatment with bezafibrate and reduced triglyceride levels reversed these microcirculatory changes, suggesting potential for monitoring atherogenesis.

Area of Science:

  • Cardiovascular Physiology
  • Microcirculation Research
  • Metabolic Disease Studies

Background:

  • Hypertriglyceridemia is linked to accelerated atherosclerosis, particularly in coronary arteries.
  • Assessing microcirculatory function in hypertriglyceridemia is crucial for understanding atherogenesis.
  • Noninvasive optical methods offer promising avenues for evaluating vascular health.

Purpose of the Study:

  • To evaluate cutaneous dynamic blood flow in hypertriglyceridemia using laser Doppler flowmetry.
  • To compare microcirculatory responses in untreated patients, treated patients, and healthy controls.
  • To investigate the reversibility of microcirculatory changes with triglyceride level reduction.

Main Methods:

  • Laser Doppler flowmetry was used to measure forearm cutaneous blood flow.

Related Experiment Videos

  • Postischemic reactive hyperemia tests were performed on 32 hypertriglyceridemia patients (15 untreated, 17 treated) and 27 controls.
  • Blood flow parameters, including peak flow, area under the curve, reaction time, and decay time, were analyzed.

    • Main Results:

    • Untreated hypertriglyceridemia patients showed significantly lower peak flow and smaller area under the curve compared to treated and control groups.
    • Microcirculatory parameters normalized in treated patients, similar to controls.
    • The treated group exhibited faster hyperemic response, while controls had a longer decay time.

    Conclusions:

    • Postischemic hyperemia tests reveal reversible cutaneous microcirculatory changes in hypertriglyceridemia.
    • These changes may stem from endothelial dysfunction, smooth muscle abnormalities, or structural vascular alterations.
    • Dynamic blood flow measurements are sensitive indicators for evaluating microvascular involvement and monitoring hypertriglyceridemia patients during atherogenesis.