Cytogenetic findings in squamous cell carcinoma of the oral cavity

A case of squamous cell carcinoma (SCC) of the oral cavity is presented which, in addition to normal metaphases, cytogenetically displayed two cell clones with chromosomal aberrations: 46,XY,1+del(5)(q13),der(18)t(5;18)(q13;p11),-5 and 49,XY,+5,+7,+10 After a review of the literature of the few cytogenetically analyzed cases, the findings confirm the multiclonal origin of oral SCC and also the commonly seen aberrations of chromosome 5.