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L-741,494, a fungal metabolite that is an inhibitor of interleukin-1 beta converting enzyme
M J Salvatore1, O D Hensens, D L Zink
1Merck Research Laboratories, Rahway, New Jersey 07065.
Journal of Natural Products
|June 1, 1994
Abstract:
gamma-Pyrone-3-acetic acid (L-741,494) is a novel metabolite produced by a culture of the fungal genus Xylaria. This substance is a water-soluble, competitive, irreversible inhibitor of Interleukin-1 beta Converting Enzyme that is inactive against papain and trypsin. It has a mol wt of 154 and an empirical formula of C7H6O4. We propose the name xylaric acid for this compound.