Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Alkaloids from Lycopodium casuarinoides

Y C Shen¹, C H Chen

¹Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.

Journal of Natural Products

|June 1, 1994

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Single-beat estimation of end-systolic pressure-volume relation in humans. A new method with the potential for noninvasive application.

Circulation·1996

Same author

A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function.

The Journal of biological chemistry·1996

Same author

Lack of association between TaqI A1 allele of dopamine D2 receptor gene and alcohol-use disorders in atayal natives of Taiwan.

American journal of medical genetics·1996

Same author

Apoptosis induced by X-irradiation of rec-myc cells is postmitotic and not predicted by the time after irradiation or behavior of sister cells.

Cancer research·1996

Same author

Thermodynamic and fluorescence studies of the underlying factors in benzyl alcohol-induced lipid interdigitated phase.

Archives of biochemistry and biophysics·1996

Same author

Expression of an avian CD6 candidate is restricted to alpha beta T cells, splenic CD8+ gamma delta T cells and embryonic natural killer cells.

European journal of immunology·1996

Same journal

Botryolides F and G from the Fungus <i>Bartalinia robillardoides</i> with Anthelmintic Activity.

Journal of natural products·2026

Same journal

Characterization of Cyclotides via LC-MS/MS from the Vietnamese Plant <i>Viola annamensis</i> Bak.f.: Insights into Antimicrobial and Larvicidal Activities.

Journal of natural products·2026

Same journal

Correction to "Structure and Absolute Configuration of Diterpenoids from <i>Hymenaea stigonocarpa</i>".

Journal of natural products·2026

Same journal

Goyangamins A-C, Three Pairs of Enantiomeric 2(1<i>H</i>)-Quinolinone Alkaloid Dimers with Antisenescent Activity from <i>Tetradium daniellii</i>.

Journal of natural products·2026

Same journal

Polycyclic-Fused Cytochalasins with Anti-Liver Fibrosis Activity Produced by the Endophytic Fungus <i>Trichoderma harzianum</i>.

Journal of natural products·2026

Same journal

Oleraciamides A and B: Confirmation and Revision of Structures.

Journal of natural products·2026

See all related articles

A new alkaloid, N-demethylhuperzinine, was isolated from Lycopodium casuarinoides. This compound demonstrated significant anticholinesterase activity in pharmacological studies, suggesting potential therapeutic applications.

Area of Science:

Phytochemistry
Pharmacology
Natural Products Chemistry

Background:

Lycopodium species are a source of bioactive alkaloids.
Huperzinine is a known alkaloid with pharmacological activity.
Exploring new compounds from natural sources is crucial for drug discovery.

Purpose of the Study:

To isolate and characterize new alkaloids from Lycopodium casuarinoides.
To evaluate the anticholinesterase activity of isolated compounds.
To identify potential therapeutic agents from plant-derived natural products.

Main Methods:

Bioassay-directed fractionation of Lycopodium casuarinoides aerial parts.
Structure elucidation using spectral analysis (NMR, mass spectrometry).
Pharmacological evaluation of anticholinesterase activity.

Related Experiment Videos

Main Results:

Isolation of a new alkaloid, N-demethylhuperzinine [2], alongside huperzinine [1].
Structural confirmation of N-demethylhuperzinine through extensive spectroscopic data and comparison.
Demonstration of anticholinesterase activity for N-demethylhuperzinine.

Conclusions:

N-demethylhuperzinine is a novel alkaloid isolated from Lycopodium casuarinoides.
The compound exhibits significant anticholinesterase properties.
N-demethylhuperzinine represents a potential candidate for further pharmacological investigation.