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Is acquired pendular nystagmus always phase locked?

¹Division of Neurology, Toronto Hospital, Ontario, Canada.

Journal of Neurology, Neurosurgery, and Psychiatry

|October 1, 1994

Summary

This study details a multiple sclerosis patient experiencing oscillopsia from acquired pendular nystagmus. The nystagmus showed unique amplitude and frequency dissociation between the eyes, with one eye oscillating twice as fast as the other.

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Area of Science:

Neuro-ophthalmology
Movement Disorders
Multiple Sclerosis Pathophysiology

Background:

Acquired pendular nystagmus can cause significant oscillopsia in patients.
Dissociated nystagmus, varying in amplitude or frequency between eyes, presents diagnostic challenges.

Observation:

A patient with multiple sclerosis (MS) presented with oscillopsia.
The patient exhibited acquired pendular nystagmus with amplitude dissociation, more pronounced in the eye showing a relative afferent pupil defect.

Findings:

Eye movement recordings revealed an unusual dissociation in nystagmus frequency.
The right eye oscillated at exactly twice the frequency of the left eye, despite the frequency difference, the eyes remained phase-locked.

Implications:

This case highlights the complex and varied presentations of nystagmus in multiple sclerosis.
Understanding dissociated nystagmus patterns is crucial for accurate diagnosis and management of neuro-ophthalmic disorders.

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