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No linkage between multiple sclerosis and the T cell receptor alpha chain locus
M Eoli1, N W Wood, H F Kellar-Wood
1University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, UK.
Journal of the Neurological Sciences
|June 1, 1994
Summary
Genetic susceptibility to multiple sclerosis (MS) is complex. This study investigated the T cell receptor alpha chain locus and found no significant linkage to MS susceptibility in UK patients.
Area of Science:
- Genetics
- Immunology
- Neurology
Background:
- Multiple sclerosis (MS) susceptibility has a genetic component, likely involving multiple genes.
- The T cell receptor (TCR) alpha chain locus on chromosome 14 is a candidate gene for MS susceptibility.
Purpose of the Study:
- To investigate the linkage between the TCR alpha chain locus and MS susceptibility in affected sibling pairs.
- To determine if the TCR alpha chain locus contributes to genetic predisposition for MS.
Main Methods:
- Utilized affected sibling pair analysis to assess genetic linkage.
- Employed high polymorphism information content markers for haplotype analysis.
- Conducted studies using restriction fragment length polymorphisms (RFLP) and microsatellite repeat polymorphisms.
- Stratified analysis based on DR15 status.
Main Results:
- No significant difference was observed in genotype or haplotype sharing compared to expected rates.
- Stratification by DR15 status did not alter haplotype distribution in affected siblings.
- The TCR alpha chain locus did not show linkage to MS susceptibility.
Conclusions:
- The T cell receptor alpha locus is not linked to multiple sclerosis susceptibility in the United Kingdom patient cohort.
- Further research is needed to identify other genetic factors contributing to MS development.