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Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
Published on: February 6, 2020
Adherence of human lens epithelial cells to conventional poly(methyl methacrylate), heparin-surface-modified, and
W J Power1, D Neylan, L M Collum
1Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
Abstract:
We developed an in vitro model to assess the adherence of human lens epithelial cells to three types of intraocular lenses: poly(methyl methacrylate) (PMMA), heparin-surface-modified PMMA (HSM-PMMA), and polyHema. Lenses were incubated with a fixed number of human lens epithelial cells. Adherent cells were counted after 72 hours in culture. Scanning electron microscopy showed significantly fewer cells adhering to the HSM-PMMA and polyHema lenses than to the PMMA lenses (P < .01). Repeat experiments on cell lines established from different donors confirmed these findings.
