Related Experiment Video
Updated: Aug 17, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Anti-Ro(SSA) antibodies in patients with rheumatoid arthritis--a possible marker for gold induced side effects
M Tishler1, B Golbrut, Y Shoenfeld
1Department of Rheumatology, Elias Sourasky Medical Center, Ichilov Hospital, Tel Aviv, Israel.
Objective:
To determine whether anti-Ro antibodies are associated with gold induced side effects.
Methods:
A retrospective chart review of 208 patients with rheumatoid arthritis (RA) and examination of sera for the presence of anti-Ro antibodies by enzyme linked immunosorbent assay.
Results:
Anti-Ro antibodies were detected in 44 (21%) of our patients with RA and their presence correlated with positive rheumatoid factor, antinuclear antibody, and secondary Sjögren's syndrome. Thirty-three out of 48 patients with gold induced side effects (69%) were anti-Ro positive in contrast to 11 patients (7.5%) with positive antibodies with no side effects (p < 0.001). Mucocutaneous reactions had the only significant correlation (p < 0.01) with the presence of anti-Ro antibodies.
Conclusion:
Patients with RA with anti-Ro antibodies are prone to develop mucocutaneous side effects to gold salts.
More Related Videos
06:37Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
Published on: September 15, 2023
04:50Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Related Concept Videos
Immunogold Electron Microscopy
Rheumatic Heart Disease I: Introduction