Related Experiment Video
Updated: Aug 8, 2026
10:18
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Ki-1 large cell anaplastic lymphoma--a clinicopathological study
Summary
This study reviews 10 Ki-1 large cell anaplastic lymphoma cases, detailing clinical and morphological features. Ki-1 lymphoma, a malignant lymphoma variant, often presents as cervical lymphadenopathy and shows pleomorphic morphology.
Area of Science:
- Oncology
- Hematopathology
- Immunohistochemistry
Background:
- Ki-1 large cell anaplastic lymphoma is an emerging variant of malignant lymphoma.
- Understanding its clinical and morphological characteristics is crucial for diagnosis.
Purpose of the Study:
- To retrospectively analyze 10 cases of Ki-1 lymphoma.
- To document the clinical and morphological features of this lymphoma variant.
Main Methods:
- Retrospective review of 10 Ki-1 lymphoma cases.
- Morphological evaluation of hematoxylin and eosin stained paraffin-embedded sections.
- Immunohistochemical staining for BER-H2 and leucocyte common antigen (LCA).
Main Results:
- Patient age ranged from 2 to 60 years, with a male to female ratio of 2.3:1.
- Cervical lymphadenopathy was the most frequent clinical presentation.
- Histologically, 8 cases showed effaced lymph node architecture; 2 had Reed-Sternberg-like cells and 7 had histiocyte-like cells.
- All cases tested positive for BER-H2 via immunohistochemistry.
Conclusions:
- Ki-1 lymphoma exhibits diverse morphological features.
- BER-H2 positivity is a consistent finding in Ki-1 lymphoma.
- Consideration of Ki-1 lymphoma is recommended for lymphomas with pleomorphic morphology.
