[Metabolic and endocrinological responses to the infusion of a new intraoperative fluid]

A new intraoperative fluid, which is characterized by containing 10 mEq.l-1 of potassium, 140 mEq.l-1 sodium and 1% glucose, was infused into 18 healthy volunteers either at rate of 5, 10 ml.kg-1.h-1 (for 3 hours) or 15 ml.kg-1.h-1 (for 2 hours). Responding to increase in the infusion rate and volume, blood glucose and insulin (IRI) levels increased slightly but remained in the normal range. On the other hand, lipid metabolism was depressed markedly. Although concentrations of both potassium and sodium in serum remained unchanged, sodium and water balance (intake vs. outflow) became absolutely positive. Potassium balance was maintained at zero. Blood renin activity decreased gradually after the infusion was commenced and remained at a lower level for 3 hours after stopping infusion. Blood aldosterone and antidiuretic hormone levels also decreased but more gradually than the decrease of blood renin activity. Noteworthy change was not observed in the variables relating to hepatic and renal functions.