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[Serum and tissue levels of cefodizime in the pediatric patients]
1First Department of Surgery, Kochi Medical School.
Insights
Cefodizime antibiotic levels remained high in pediatric patients after surgery for simple hernia. This injectable medication showed sustained tissue concentrations and no observed side effects, indicating safety and efficacy.
Area of Science:
- Pharmacology
- Pediatric Surgery
- Infectious Diseases
Background:
- Antibiotic prophylaxis is crucial in pediatric surgery to prevent surgical site infections.
- Cefodizime is a cephalosporin antibiotic with broad-spectrum activity.
- Understanding drug distribution and persistence in pediatric patients is essential for optimizing treatment regimens.
Purpose of the Study:
- To evaluate the pharmacokinetic profile of cefodizime in pediatric patients undergoing simple herniorrhaphy.
- To determine cefodizime concentrations in serum and tissue at various time points post-administration.
- To assess the safety and efficacy of cefodizime as an injectable antibiotic in this patient population.
Main Methods:
- Administration of cefodizime (40 mg/kg) to 13 pediatric patients with simple herniorrhaphy.
- Measurement of cefodizime concentrations in serum and surgical tissue samples.
- Pharmacokinetic analysis of drug levels over time.
Main Results:
- Mean serum cefodizime concentration was 43.1 +/- 13.3 µg/ml at 3 hours.
- Mean tissue cefodizime concentration was 23.1 +/- 6.4 µg/g at 3 hours.
- Sustained high cefodizime levels were observed in both serum and tissue, with slower elimination from tissue compared to serum.
Conclusions:
- Cefodizime demonstrates favorable pharmacokinetic properties, with prolonged tissue retention in pediatric surgical patients.
- The antibiotic was found to be safe and effective, with no adverse events reported.
- Cefodizime is a suitable injectable antibiotic option for infection prevention and treatment in pediatric surgical cases.
Abstract:
We administrated cefodizime (40 mg/kg) to 13 patients with simple herniorrhaphy in the pediatric field and determined its concentrations in tissues and serums. The mean serum and tissue levels of cefodizime after administration were 43.1 +/- 13.3 micrograms/ml, and 23.1 +/- 6.4 micrograms/g, respectively, at 3 hours. Cefodizime concentrations of the tissue and serum were maintained at relatively high levels for many hours. The ratio of cefodizime concentrations in tissue to serum became high at 3 hours after administration, and this suggests that tissue concentrations decreased more slowly than serum levels, and cefodizime concentrations in tissue were maintained at fairly high levels over a long period. No side effects caused by cefodizime were observed. From pharmacokinetic and clinical observations, cefodizime appears to be a safe and effective injectable antibiotic for the treatment of infections in children.