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[B-lymphoma arising in the temporal muscle]
R Kageyama1, T Takashima, M Taniwaki
1Third Department of Internal Medicine, Kyoto Prefectural University of Medicine.
Summary
This case study details a rare instance of B cell lymphoma in skeletal muscle. The patient achieved complete remission with combination chemotherapy, highlighting effective treatment options for this uncommon condition.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- B cell lymphoma is a malignant proliferation of lymphocytes.
- Skeletal muscle involvement by lymphoma is exceptionally rare.
- Accurate diagnosis and staging are crucial for effective treatment.
Observation:
- A 72-year-old male presented with a gradually enlarging right temporal mass.
- Imaging revealed a soft tissue mass in the temporal and infratemporal fossae.
- Histopathology confirmed B cell lymphoma, diffuse medium-sized cell type.
- Immunophenotyping showed positivity for CD5, CD19, CD20, SmIg mu, delta, lambda, and negativity for CD10.
- Karyotyping revealed complex clonal aberrations: 51, X, +X, -Y, +2, +3, +4, +8, +12.
Findings:
- The patient was diagnosed with skeletal muscle B cell lymphoma.
- The tumor exhibited specific surface marker and chromosomal abnormalities.
- Complete remission was achieved following multi-agent chemotherapy.
Implications:
- This case expands the understanding of extranodal B cell lymphoma presentations.
- It underscores the importance of considering lymphoma in soft tissue masses.
- Successful treatment with combination chemotherapy offers a therapeutic precedent.