Related Experiment Video
Updated: Aug 11, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
[Pathways leading to intractable vasculitis syndromes: a review]
1Department of Pathology, Hokkaido University School of Medicine.
Abstract:
Intractable vasculitis syndromes are reviewed in terms of pathways leading to the diseases. The III-type, IV-type, and II-type allergic reaction, as well as angiospasm and endothelial dysfunction pathways are important in the pathogenesis of vasculitis. Each pathway has been described, using appropriate animal models or experimental and clinical data. Antigens of microorganisms are, among others, important pathogenic factors, activating several pathways. Endogenous retroviral antigens in the mouse, and possibly in humans, cause vasculitis through the II-type and III-type hypersensitivity, and experiments on the intractable vasculitis remain to be focused on this point.
Related Concept Videos
Overview of the Vascular System
Rheumatic Heart Disease I: Introduction
Venous Thrombosis I: Introduction
Nephrotic Syndrome I : Introduction
Encephalitis ll: Pathophysiology
Portal Hypertension

