[Markers of coagulation/fibrinolysis in angitis]

Endothelial cells exhibit antithrombogenic properties, including PGI2 and NO production which inhibit platelet functions and induce blood vessel dilatation. Endothelium also produces thrombomodulin which converts thrombin from a procoagulant protease to an anticoagulant. These antithrombogenic properties are altered by several factors, which include inflammatory cytokines (IL-1, TNF) resulting hypercoagulable state in inflammation. Thus increased markers of coagulation/fibrinolysis were observed in angitis syndrome. The hypercoagulable state showing the activity of angitis may cause thrombosis and may act as a progressive factor for angitis.