Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Malignant rheumatoid arthritis]

T Aikawa1

  • 1Department of Internal Medicine, Sagamihara National Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Malignant rheumatoid arthritis (MRA), or rheumatoid vasculitis, involves rheumatoid arthritis with vasculitis, presenting diverse symptoms. Immune complexes, particularly those with rheumatoid factor (RF), are implicated in its vascular lesions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cervical intervertebral disc disease in 307 small-breed dogs (2000-2021): Breed-characteristic features and disc-associated vertebral instability.

Australian veterinary journal·2024
Same author

Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base Synchondrosis.

Journal of dental research·2023
Same author

Vertebral stabilisation for thoracolumbar vertebral instability associated with cranial and caudal articular process anomalies in pugs: Seven cases (2010-2019).

The Journal of small animal practice·2022
Same author

Incidence of Abnormalities of the Second and Third Cervical Vertebral Junction in Dogs with Atlantoaxial Instability: A Multicentre Study.

Veterinary and comparative orthopaedics and traumatology : V.C.O.T·2017
Same author

A drug formulation using an alginate hydrogel matrix for efficient oral delivery of the manganese porphyrin-based superoxide dismutase mimic.

Biomaterials science·2015
Same author

A novel and rapid diagnostic method for discriminating between feces of sika deer and Japanese serow by loop-mediated isothermal amplification.

Mammalian genome : official journal of the International Mammalian Genome Society·2015
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Area of Science:

  • Rheumatology
  • Immunology
  • Pathology

Context:

  • Malignant rheumatoid arthritis (MRA) is a severe form of rheumatoid arthritis characterized by systemic vasculitis.
  • It is commonly referred to as rheumatoid vasculitis in Western countries.
  • MRA presents with a wide spectrum of clinical manifestations due to vascular inflammation.

Purpose:

  • To elucidate the clinical features, potential causes, and treatment strategies for malignant rheumatoid arthritis (MRA).
  • To highlight the role of immune complexes and rheumatoid factor (RF) in the pathogenesis of MRA.
  • To discuss the therapeutic approaches for managing MRA, including corticosteroids and immunosuppressants.

Summary:

  • MRA is defined by the presence of vasculitis in patients with rheumatoid arthritis.

Related Experiment Videos

  • Clinical manifestations are diverse, including skin ulcers, nodules, and involvement of multiple organs such as the heart, lungs, and gastrointestinal tract.
  • Pathogenesis is linked to immune complex deposition, particularly involving self-associated IgG rheumatoid factor (RF).

    • Impact:

    • Understanding the pathogenesis of MRA can lead to targeted therapies for this debilitating condition.
    • Effective management strategies, including steroid therapy and immunosuppressants, are crucial for severe cases.
    • This research contributes to the broader understanding of autoimmune diseases and vasculitis.