Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Scleroderma, dermatomyositis]

A Yamakage1

  • 1Department of Dermatology, Dokkyo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis, a progressive connective tissue disease, involves skin and organ hardening. Growth factors like TGF-beta and PDGF may drive its pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis.

The British journal of dermatology·2002
Same author

The polymorphism of telomerase RNA component gene in patients with systemic sclerosis.

The British journal of dermatology·2002
Same author

Quantitative analysis of microchimerism in systemic sclerosis skin tissue.

Archives of dermatological research·2001
Same author

Sarcoidosis with giant parotomegaly.

Cutis·2001
Same author

Evaluation of dermal fibrosis using computer-based image analysis in patients with connective tissue diseases.

Archives of dermatological research·2001
Same author

Hydroa vacciniforme with latent Epstein-Barr virus infection.

The British journal of dermatology·2001

Area of Science:

  • Connective tissue diseases
  • Pathogenesis of scleroderma
  • Dermatomyositis etiology

Context:

  • Systemic sclerosis (SSc) is a severe, progressive disorder affecting skin, joints, and internal organs.
  • Pathological hallmarks include abnormal mucopolysaccharides, fibrosis, atrophy, and vascular insufficiency.
  • Dermatomyositis shares characteristics like inflammation and vascular issues, with unknown causes.

Purpose:

  • To explore the potential roles of specific molecular pathways in SSc pathogenesis.
  • To investigate the involvement of growth factors and proteoglycans in scleroderma.
  • To provide insights into the complex etiology of connective tissue diseases.

Summary:

  • Scleroderma is characterized by skin and organ sclerosis, fibrosis, and vascular problems.

Related Experiment Videos

  • Transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) interactions are implicated in SSc.
  • Proteoglycans may modulate growth factor activity, influencing disease progression.

    • Impact:

    • Highlights key molecular players in systemic sclerosis pathogenesis.
    • Suggests potential therapeutic targets for managing scleroderma.
    • Enhances understanding of complex connective tissue disorders like dermatomyositis.