Autoimmune phenomenon in Mooren's ulcer

Direct immunofluorescent techniques demonstrated immunoglobulins localized to the conjunctival epithelium in three cases of Mooren's ulcer. In addition, complement was found in association with the immunoglobulins in the two active cases. Circulating antibodies to the conjunctival and corneal epithelium were demonstrated by indirect immunofluorescent techniques in all three patients. Further immunological examinations of the three cases failed to demonstrate other significant immune alterations.