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Persistent polyclonal B-cell lymphocytosis
1Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, U.K.
Leukemia Research
|October 1, 1994
Abstract:
We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smoking and raised levels of IgM, all of which were present in our patient.