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Related Experiment Videos

Ipratropium bromide protects against bronchoconstriction during bronchoscopy

H Inoue1, H Aizawa, S Takata

  • 1Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Lung
|January 1, 1994
PubMed
Summary

Inhaled ipratropium bromide prevents lung function decline during bronchoscopy, unlike atropine. This study highlights inhaled ipratropium bromide

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Area of Science:

  • Pulmonology
  • Pharmacology

Background:

  • Fiberoptic bronchoscopy can impair pulmonary function.
  • Anticholinergic agents are explored for mitigating bronchoconstriction during procedures.

Purpose of the Study:

  • To investigate the protective effects of inhaled ipratropium bromide and intramuscular atropine against bronchoconstriction during diagnostic bronchoscopy.

Main Methods:

  • 29 patients undergoing bronchoscopy were divided into three groups: atropine, ipratropium bromide, or placebo.
  • Pulmonary function (FEV1, PEFR) was measured before and after anticholinergic/placebo administration, topical anesthesia (lidocaine), and bronchoscopy.

Main Results:

  • Inhaled ipratropium bromide prevented significant reductions in FEV1 and PEFR caused by topical anesthesia and bronchoscopy.

Related Experiment Videos

  • Topical anesthesia and bronchoscopy significantly reduced pulmonary function in placebo and atropine groups.
  • Intramuscular atropine did not protect against bronchoconstriction.

    • Conclusions:

    • The bronchoconstrictive effects of bronchoscopy are primarily due to topical lidocaine anesthesia and the procedure itself.
    • Inhaled ipratropium bromide effectively protects pulmonary function during fiberoptic bronchoscopy.
    • Intramuscular atropine offers no protection against these effects.