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Updated: Aug 9, 2026

Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
Published on: May 17, 2019
[Morphologic changes in the pulp and surrounding structures of the teeth in irradiated animals]
I Selak1, M Seremet, Z Milosević
1Institut za patolosku anatomiju, Medicinski fakultet Sarajevo.
Abstract:
Several animals of the same breed (11 swine-white Landrace) were used in the research. Irradiation was made by radiation from the linear accelerator with lethal doses (3,68-4, 48 Gy). The changes on incisors and molars in the perished animals were observed as well as the changes on the surrounding structures of teeth. In the examined histological incisions of the dental pulp, paradontium, alveolar part of the bone and gingival part of the mucose of the oral cavity in the animals were found extensive confluent bleeding, dilatation of blood vessels with expressive edema of blood vessels intima. The endothelium showed the signs of edema, prominence toward the lumen or desquamation in the lumen. There were shallow defects in the gingival mucosa due to the necrosis and desquamation top-cover epithelium. The described changes fit into the findings of a large number of researches who accent hemorrhagic diathesis with petechial ecchymotic and confluent bleedings in many organs and tissues.
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The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.

