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Secondary-sites for integration mediated by the Tn21 integrase
M V Francia1, F de la Cruz, J M García Lobo
1Departamento de Biología Molecular, Universidad de Cantabria, Santander, Spain.
Molecular Microbiology
|November 1, 1993
Abstract:
The integrase encoded by the integron of the transposon Tn21 can mediate the site-specific fusion of two plasmids if there is a recombination hot spot (59 bp element) in one of them and the sequence GWTMW in the other. The use of this latter, loosely defined site explains how antibiotic-resistance genes could first become associated with integrons.