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Frequency of deletion formation decreases exponentially with distance between short direct repeats
1Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy en Josas, France.
Molecular Microbiology
|May 1, 1994
Abstract:
The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility. A similar relationship between deletion formation and distance was observed in a theta-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.