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Updated: Oct 23, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Two cases of exogenous endophthalmitis due to Fusarium moniliforme and Pseudomonas species as associated aetiological

N Srdić1, S Radulović, Z Nonković

  • 1Institute for Microbiology, Military Medical Academy, Belgrade, Serbia.

Mycoses
|November 1, 1993
PubMed

Insights

Fulminant endophthalmitis complicated perforative eye injuries. Metal foreign bodies facilitated fungal and bacterial penetration into the vitreous body, causing severe ocular infections.

Area of Science:

  • Ophthalmology
  • Medical Mycology
  • Medical Microbiology

Background:

  • Perforative eye injuries can lead to severe intraocular infections.
  • Endophthalmitis, an inflammation of the eye's interior, poses a significant threat to vision.

Observation:

  • Two patients with perforative eye injuries developed fulminant endophthalmitis.
  • Corneal examination revealed no microorganisms in either patient.
  • Vitrectomy was performed to examine the vitreous humor.

Findings:

  • Fusarium moniliforme var. subglutinans (fungal) and Pseudomonas species (bacterial) were isolated from the vitreous.
  • Microorganisms were found to have penetrated the vitreous cavity via retained metal foreign bodies.

Implications:

  • Metal foreign bodies are a critical route for microbial entry in perforative eye injuries.
  • Prompt and thorough investigation is crucial for identifying causative agents in endophthalmitis.
  • Understanding microbial pathways is essential for effective treatment and prevention strategies in ocular trauma.

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