Trichosporon on humans: a practical account
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E Guého1, L Improvisi, G S de Hoog
1Unité de Mycologie, Institut Pasteur, Paris, France.
Abstract:
Six human pathogenic Trichosporon species are described with respect to criteria for routine identification, epidemiology and clinical origin: T. ovoides, T. inkin, T. asahii, T. asteroides (Fissuricella filamenta), T. cutaneum, and T. mucoides. These species are causative agents of white piedra and cutaneous infections and are involved in systemic, localized or disseminated mycoses, particularly in patients with underlying haematological malignancy. Data on in vitro sensitivity to antifungal drugs are provided.
Insights
This study details six pathogenic Trichosporon species, their identification, and clinical relevance in causing infections like white piedra, especially in immunocompromised patients. Antifungal drug sensitivity data is also included for these fungi.
Area of Science:
- Medical Mycology
- Clinical Microbiology
Background:
- Trichosporon species are emerging fungal pathogens.
- These fungi cause superficial and systemic mycoses.
- Patients with hematological malignancies are particularly susceptible.
Purpose of the Study:
- To describe six key human pathogenic Trichosporon species.
- To provide criteria for their routine identification.
- To outline their epidemiology, clinical origins, and antifungal sensitivities.
Main Methods:
- Morphological and biochemical characterization of Trichosporon isolates.
- Review of epidemiological and clinical case data.
- In vitro antifungal susceptibility testing.
Main Results:
- Detailed descriptions of T. ovoides, T. inkin, T. asahii, T. asteroides, T. cutaneum, and T. mucoides.
- Identification criteria for routine laboratory use.
- Association with white piedra, cutaneous infections, and systemic mycoses in immunocompromised hosts.
Conclusions:
- Accurate identification of Trichosporon species is crucial for patient management.
- Understanding the epidemiology and clinical spectrum aids in early diagnosis.
- In vitro antifungal data guides therapeutic decisions for Trichosporon infections.