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Related Experiment Videos

Clinico-pathological studies on experimental cryptococcal mastitis in goats

M Singh1, P P Gupta, J S Rana

  • 1Department of Veterinary Pathology, Punjab Agricultural University, Ludhiana, India.

Mycopathologia
|June 1, 1994
PubMed
Summary

Intramammary inoculation of goats with Cryptococcus neoformans caused severe mastitis, localized to one udder half. This infection led to reduced milk yield and significant udder tissue changes without systemic spread.

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Area of Science:

  • Veterinary Mycology
  • Infectious Diseases
  • Pathology

Background:

  • Cryptococcus neoformans is an opportunistic fungal pathogen.
  • Mastitis is a significant concern in dairy animals, impacting milk production and animal welfare.

Purpose of the Study:

  • To investigate the pathological effects of Cryptococcus neoformans intramammary inoculation in goats.
  • To assess the course and localization of fungal mastitis in a caprine model.

Main Methods:

  • Ten goats were inoculated unilaterally in the udder with Cryptococcus neoformans.
  • Animals were monitored for 40 days, with necropsies performed at set intervals.
  • Milk yield, gross pathology, and histopathology of udder tissues were evaluated.

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Main Results:

  • Infection remained localized to the inoculated udder half, with no systemic dissemination.
  • Mastitis was characterized by initial enlargement followed by shrinkage, nodularity, and fibrosis.
  • Significant reduction in milk yield was observed post-infection.
  • Cryptococcus neoformans was reisolated from milk and detected in udder tissues up to 25-30 days post-inoculation.

Conclusions:

  • Intramammary Cryptococcus neoformans infection in goats causes severe, localized mastitis.
  • The infection leads to significant pathological changes in the udder and a sharp decline in milk production.
  • Goats can serve as a model for studying fungal mastitis, highlighting the localized nature of the disease.