Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Chronic recurrent polychondritis]

A E van Ede1, H M Brink, C C Tilanus

  • 1Afd. Algemene Inwendige Geneeskunde, Academisch Ziekenhuis, Nijmegen.

Nederlands Tijdschrift Voor Geneeskunde
|September 24, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SWOT analysis of decentralised clinical trials from an ethical, legal, regulatory and operational perspective.

BMC medical ethics·2026
Same author

Personal-professional Development Program Fosters Resilience During COVID-Pandemic.

Journal of medical education and curricular development·2022
Same author

Development and measurement of perioperative patient safety indicators.

British journal of anaesthesia·2015
Same author

Meta-analysis of operative mortality and complications in patients from minority ethnic groups.

The British journal of surgery·2014
Same author

Detection and quantitation of gallid herpesvirus 1 in avian samples by 5' Taq nuclease assay utilizing Minor Groove Binder technology.

Avian pathology : journal of the W.V.P.A·2010
Same author

Three methods of multi-source feedback compared: a plea for narrative comments and coworkers' perspectives.

Medical teacher·2010

Relapsing polychondritis is a rare autoimmune disease affecting cartilage. Early diagnosis and treatment with anti-inflammatory drugs, steroids, or immunosuppressants are crucial for managing this condition.

Area of Science:

  • Rheumatology
  • Immunology
  • Genetics

Background:

  • Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by progressive inflammation and destruction of cartilaginous tissues.
  • The exact etiology of RP remains unclear, but autoimmune mechanisms are strongly suspected, involving both humoral and cellular immunity.
  • RP affects various cartilaginous structures, including the auricles, nasal septum, joints, larynx, trachea, and eyes, leading to significant morbidity.

Observation:

  • A 71-year-old female presented with recurrent fever, dry cough, pain on inspiration, hoarseness, and severe inflammation of auricular cartilage.
  • Clinical diagnosis of relapsing polychondritis was established based on characteristic symptoms and confirmed via cartilage biopsy.
  • The patient experienced recurrent episodes, highlighting the chronic and relapsing nature of the disease.

Related Experiment Videos

Findings:

  • The case illustrates the diverse clinical manifestations of relapsing polychondritis, emphasizing auricular chondritis as a prominent symptom.
  • Diagnosis can be challenging due to the rarity and variable presentation of RP, underscoring the importance of clinical suspicion and diagnostic confirmation.
  • Cartilage biopsy serves as a valuable tool for confirming the diagnosis of relapsing polychondritis.

Implications:

  • Early diagnosis and prompt initiation of treatment are essential to mitigate disease progression and prevent severe complications in relapsing polychondritis.
  • Therapeutic strategies for RP include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressive agents, tailored to disease severity and affected organs.
  • Understanding the autoimmune basis of RP may pave the way for targeted immunotherapies and improved long-term management strategies.