Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serial changes in hemostasis after intracranial surgery

Y Fujii1, R Tanaka, S Takeuchi

  • 1Department of Neurosurgery, Niigata University, Japan.

Neurosurgery
|July 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025

Intracranial surgery activates blood coagulation and platelet function transiently, while fibrinolysis shows a biphasic response. General anesthesia did not significantly impact hemostasis during these neurosurgical procedures.

Area of Science:

  • Neurosurgery
  • Hemostasis
  • Coagulation and Fibrinolysis

Background:

  • Intracranial surgery for unruptured cerebral aneurysms presents a unique context for studying hemostatic changes.
  • Understanding the impact of neurosurgery on blood clotting and fibrinolysis is crucial for patient management.

Purpose of the Study:

  • To investigate the serial changes in hemostatic parameters following intracranial surgery.
  • To assess the influence of the surgical procedure itself, independent of anesthesia, on the hemostatic system.

Main Methods:

  • Serial blood sampling from eight patients undergoing aneurysm clipping.
  • Measurements included thrombin-antithrombin III, plasmin-alpha 2-antiplasmin, D-dimer, tissue plasminogen activator, plasminogen activator inhibitor-1, beta-thromboglobulin, platelet-factor-4, fibrinogen, alpha 2-antiplasmin, hematocrit, fibronectin, antithrombin III, and plasminogen.

Related Experiment Videos

  • Sampling occurred at multiple time points: pre-anesthesia, post-anesthesia, and up to 7 days post-surgery.

    • Main Results:

    • Coagulation activation (thrombin-antithrombin III) was transient and monophasic.
    • Fibrinolysis (plasmin-alpha 2-antiplasmin, D-dimer) and platelet activation (beta-thromboglobulin, platelet-factor-4) exhibited biphasic responses.
    • Acute phase reaction markers like fibrinogen and alpha 2-antiplasmin increased postoperatively.
    • Hematocrit changes correlated with platelet count and levels of antithrombin III and plasminogen.
    • Fibronectin was consumed during the acute postoperative phase.
    • General anesthesia did not significantly alter hemostasis.

    Conclusions:

    • Intracranial surgery triggers complex, time-dependent activation of coagulation, fibrinolysis, and platelet systems.
    • The observed hemostatic changes are likely linked to the surgical stress and subsequent acute phase reaction.
    • Hemostatic monitoring can provide insights into the body's response to neurosurgical interventions.