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The 16S ribosomal RNA mutation database (16SMDB)

K L Triman1

  • 1Department of Biology, Franklin and Marshall College, Lancaster, PA 17604.

Nucleic Acids Research
|September 1, 1994
PubMed
Summary

The 16S ribosomal RNA mutation database (16SMDB) catalogs mutations in Escherichia coli 16S ribosomal RNA. It details mutation effects, detection methods, and literature for researchers studying bacterial genetics.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Bioinformatics

Background:

  • 16S ribosomal RNA (rRNA) is crucial for bacterial protein synthesis and widely used in taxonomy.
  • Understanding mutations in 16S rRNA is vital for studying bacterial adaptation and antibiotic resistance.
  • Existing resources for cataloging 16S rRNA mutations are fragmented.

Purpose of the Study:

  • To create a centralized database of mutations in Escherichia coli 16S ribosomal RNA (16SMDB).
  • To provide comprehensive information on each mutation, including phenotypic effects and detection methods.
  • To facilitate research on 16S rRNA function and evolution.

Main Methods:

  • Compilation of mutation data from scientific literature.
  • Annotation of mutation positions and alterations in Escherichia coli 16S rRNA.
  • Inclusion of phenotypic data (in vivo/in vitro) and literature citations.

Main Results:

  • The 16SMDB contains a curated list of mutated positions in Escherichia coli 16S rRNA.
  • Each entry details the specific alteration and associated phenotypes.
  • Information on experimental detection (in vivo/in vitro) and references is provided.

Conclusions:

  • The 16SMDB serves as a valuable resource for researchers investigating 16S rRNA mutations.
  • This database aids in understanding the functional consequences of 16S rRNA alterations in bacteria.
  • The centralized data promotes further research in bacterial genetics and molecular evolution.

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