The HSSP database of protein structure-sequence alignments
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Updated: Nov 11, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
1Protein Design Group, European Molecular Biology Laboratory, Heidelberg, Germany.
Abstract:
HSSP (homology-derived structures of proteins) is a derived database merging structural (2-D and 3-D) and sequence information (1-D). For each protein of known 3D structure from the Protein Data Bank, the database has a file with all sequence homologues, properly aligned to the PDB protein. Homologues are very likely to have the same 3D structure as the PDB protein to which they have been aligned. As a result, the database is not only a database of sequence aligned sequence families, but it is also a database of implied secondary and tertiary structures.
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