Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The HSSP database of protein structure-sequence alignments

C Sander1, R Schneider

  • 1Protein Design Group, European Molecular Biology Laboratory, Heidelberg, Germany.

Nucleic Acids Research
|September 1, 1994
PubMed
Summary

The HSSP database links protein sequence data with 3D structural information. It provides aligned sequence families, enabling prediction of protein secondary and tertiary structures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depressive and anxiety symptoms in individuals with Long-COVID: Does social network matter? - Results of a German Long-COVID study.

Journal of affective disorders·2026
Same author

Do values and political attitudes affect help-seeking? Exploring reported help-seeking for mental health problems in a general population sample using a milieu framework.

Epidemiology and psychiatric sciences·2023
Same author

Serum BDNF levels correlate with regional cortical thickness in minor depression: a pilot study.

Scientific reports·2020
Same author

Measurements of the associated production of a Z boson and b jets in pp collisions at <math> </math>.

The European physical journal. C, Particles and fields·2020
Same author

Study of Jet Quenching with Z+jet Correlations in Pb-Pb and pp Collisions at sqrt[s]_{NN}=5.02  TeV.

Physical review letters·2017
Same author

Searches for pair production of third-generation squarks in [Formula: see text][Formula: see text] pp collisions.

The European physical journal. C, Particles and fields·2017

Area of Science:

  • * Structural bioinformatics
  • * Computational biology
  • * Protein science

Background:

  • * Protein Data Bank (PDB) provides experimentally determined 3D protein structures.
  • * Sequence homology is often indicative of structural similarity.
  • * Integrating sequence and structure data is crucial for understanding protein function.

Purpose of the Study:

  • * To introduce the HSSP (homology-derived structures of proteins) database.
  • * To demonstrate the utility of merging 1-D sequence and 2-D/3-D structural information.
  • * To provide a resource for inferring protein structures from sequence data.

Main Methods:

  • * Creation of a derived database by merging PDB structural data with sequence information.
  • * Alignment of sequence homologues to known 3D structures from the PDB.
  • * Utilizing sequence alignments to infer secondary and tertiary structures.

Main Results:

  • * HSSP database successfully integrates sequence and structural data for proteins.
  • * Identified sequence homologues are aligned to PDB proteins, implying similar 3D structures.
  • * The database serves as a repository of aligned sequence families with implied structures.

Conclusions:

  • * HSSP database facilitates the study of protein structure-function relationships.
  • * It offers a valuable tool for predicting protein structures based on sequence homology.
  • * The integrated approach enhances the understanding of protein structural biology.

Related Experiment Videos