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GRBase, a new gene regulation data base available by anonymous ftp

B Collier1, M Danielsen

  • 1Trevigen Inc., Gaithersburg, MD 20877.

Nucleic Acids Research
|September 1, 1994
PubMed
Summary

The Gene Regulation Database (GRBase) compiles eukaryotic gene expression control protein data. Future updates will enhance its scope with reviews and online search capabilities for researchers.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Gene expression regulation is crucial for eukaryotic cellular function.
  • Understanding proteins involved in gene regulation is key to deciphering complex biological processes.
  • Existing resources may lack comprehensive, integrated information on these proteins.

Purpose of the Study:

  • To introduce the Gene Regulation Database (GRBase) as a centralized resource.
  • To provide information on the structure and function of eukaryotic gene regulatory proteins.
  • To make this data accessible for research and further study.

Main Methods:

  • Compilation of data on transcription factors, signal transduction proteins, and receptors.
  • Data organization and storage in accessible formats (Filemaker Pro, text, postscript).
  • Distribution via FTP for broad accessibility.

Main Results:

  • GRBase serves as a compendium of protein information critical for gene expression control.
  • The database currently includes data on key regulatory protein types.
  • Accessible data formats facilitate integration into various research workflows.

Conclusions:

  • GRBase offers a valuable resource for scientists studying eukaryotic gene regulation.
  • Planned expansions will increase the database's utility with reviews and online search.
  • The database aims to support advancements in understanding gene control mechanisms.

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