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Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases
M McClelland1, M Nelson, E Raschke
1California Institute of Biological Research, La Jolla 92037.
Nucleic Acids Research
|September 1, 1994
Abstract:
Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes.