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Related Experiment Videos

Does ranitidine affect blood alcohol concentrations?

G A Pipkin1, J G Mills, J R Wood

  • 1Department of Gastroenterology, Glaxo Research and Development, Ltd., Uxbridge, United Kingdom.

Pharmacotherapy
|May 1, 1994
PubMed
Summary
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Ranitidine does not significantly interact with alcohol. Small increases in blood alcohol concentration may occur at lower doses but are not clinically significant.

Area of Science:

  • Pharmacology
  • Toxicology

Background:

  • Ranitidine is a common medication.
  • Alcohol consumption is widespread.

Purpose of the Study:

  • To investigate potential interactions between ranitidine and alcohol.
  • To determine the clinical significance of any observed effects.

Main Methods:

  • Administering varying doses of alcohol to subjects.
  • Measuring blood alcohol concentrations with and without ranitidine.
  • Considering factors like fed vs. fasted state and food intake.

Main Results:

  • No interaction observed at higher alcohol doses (≥ 0.3 g/kg).
  • Minor increases (2-4 mg/dl) in blood alcohol concentration at lower doses (0.15 g/kg) under specific conditions.

Related Experiment Videos

  • Peak blood alcohol concentrations remained below 20 mg/dl, considered low.
  • Food intake influenced alcohol absorption, with smaller changes when taken with food.

    • Conclusions:

    • Ranitidine does not pose a significant interaction risk with alcohol.
    • Observed pharmacokinetic effects are clinically insignificant.
    • Patients can generally consume alcohol in moderation while taking ranitidine.